- In the first days of the new year Dinu Lipatti marries Madeleine Cantacuzino (née Dannhauer), after having waited for a long divorce to finalize.
- April 4: because of his health issues which were becoming more and more serious, he resigns from his position as a professor at the Geneva Conservatory but promises to hold, each year, a special, one-month course. Nikita Magaloff is appointed as his successor.
- April: he finishes work on his Aubade for wind quartet.
- Lipatti postpones his American concerts.
- Complications in his health appear, with the decalcification of the vertebrae; he continues his transfusions and his X-ray therapy.
- At the initiative of Henri Gagnebin, the director of the Geneva Conservatory, he is offered a subvention of 28,000 Swiss Francs.
- The beginning of the year sees Lipatti leaving the sanatorium and returning to Geneva.
- February 22: he plays at Victoria Hall, with the Suisse Romande Orchestra and conductor Ernest Anserment.
- He begins drafting a course on piano interpretation for the Geneva Conservatory.
- Lipatti moves to Chêne-Bourg near Geneva, in a house offered to him by his friends, who also present him with a Steinway piano.
- Igor Markevitch’s daughter is baptised, Lipatti being the godfather.
- Through the efforts of a group of famous musicians (Münch, Sacher, Stravinsky, Menuhin), he is able to try a new medicine from the US - the cortisone, which gives him the illusion of an improved health.
- Lipatti’s friend and doctor, Henri Dubois-Ferrière, announces Columbia Records via its artistic director Walter Legge that the pianist is in very good shape and able to do the planned series of recordings.
- July 2 – July 12: he records, in Geneva, music by Chopin (the waltzes and Mazurka op. 50 no. 3), Bach (Partita in B flat major, Siciliana, and three chorales, among which “Jesu bleibet meine Freude”) and Mozart (Sonata in A minor, K 310). The project of a new series of recordings (with works by Bach, Beethoven and Schumann) for that October is born. It was never carried out.
- September 2: he makes his last appearance with an orchestra, playing, in Lucerne, Mozart’s Piano concerto no. 21 in C major under Herbert von Karajan.
- September 16: Lipatti gives what would be his last recital, in the Besançon Festival. His programme featured Bach’s Partita in B flat major, Mozart’s Sonata in A minor, K 310, two of Schubert’s impromptus and Chopin’s waltzes. Weakened, he is unable to play the last waltz from the programme. After a short break, he returns in the concert hall and plays Bach’s “Jesu bleibet meine Freude”.
- Back to Chêne-Bourg, he is, again, overcome by his illness.
- After seven years of fruitless attempts to see her son, Ana Lipatti succeeds in leaving Romania and arrives in Geneva, where she can see her son again.
- December 2: Lipatti dies, in Chêne-Bourg.